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celecoxib (celebrex)

available over the counter: no

uses: pain, inflammation, stiffness of osteoarthritis and rheumatoid arthritis

mechanism of action: inhibits the enzyme cyclooxygenase 2 (COX-2), therefore reducing synthesis of prostaglandins (chemicals in the body which play a role in pain and inflammation);  does not inhibit activity of COX-1, an enzyme involved in the synthesis of prostaglandins which protect the stomach against ulcers

side effects
• common:
indigestion, diarrhea, abdominal pain
• less common: swelling, flatulence, sore throat
• serious: gastric ulcers, tarry stools, liver disease

concerns: do not take with other NSAIDS (non steroidal anti-inflammatory drugs); notify your doctor if you are taking furosemide, ACE inhibitors, fluconazole, lithium, or warfarin


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