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salsalate (amigesic, disalcid, salflex)

available over the counter: no

uses: for treatment of rheumatoid arthritis and osteoarthritis

mechanism of action: interferes with action of prostaglandins ( cause inflammation and make nerves more sensitive)

side effects
• common:
abdominal cramps, indigestion, nausea, vomiting,
• less common: none
• serious: blood in urine, severe diarrhea, difficulty swallowing, lightheadedness, confusion, seizures, tarry stools

concerns: use caution if you have anemia, ulcers, hyperthyroidism, glucose-6-phosphate dehydrogenase deficiency, hypertension, gout, heart disease, bleeding disorders, or asthma;  prolonged use may cause gastrointestinal problems, ulcers, kidney and liver dysfunction


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